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1

Prevalence and causes of blindness and vision impairment: magnitude, temporal trends and projections in South and Central Asia

Nangia, Vinay, Jonas, Jost B, George, Ronnie, Lingam, Vijaya, Ellwein, Leon, Cicinelli, Maria Vittoria, Das, Aditi, Flaxman, Seth R, Keeffe, Jill E, Kempen, John H, Leasher, Janet, Limburg, Hans, Naid

Journal:

British Journal of Ophthalmology

Year:

2018

Language:

english

File:

PDF, 619 KB

english, 2018

2

Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma

Léon C.L.T. van Kempen, Jos Rijntjes, Ine Mamor-Cornelissen, Silvia Vincent-Naulleau, Marie-Jeanne P. Gerritsen, Dirk J. Ruiter, Marcory C.R.F. van Dijk, Claudine Geffrotin, Goos N.P. van Muijen

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 854 KB

english, 2008

3

Intratumoral rhIL-12 administration in head and neck squamous cell carcinoma patients induces B cell activation

Carla M.L. van Herpen, Robbert van der Voort, Jeroen A.W.M. van der Laak, Ina S. Klasen, Aniek O. de Graaf, Léon C.L. van Kempen, I. Jolanda M. de Vries, Tjitske Duiveman-de Boer, Harry Dolstra, Ruurd

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 454 KB

english, 2008

4

Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression

Delphine Javelaud, Leon van Kempen, Vasileia I Alexaki, Erwan Le Scolan, Kunxin Luo, Alain Mauviel

Journal:

Molecular Cancer

Year:

2011

Language:

english

File:

PDF, 1.50 MB

english, 2011

5

Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma

Léon CLT van Kempen, Jos Rijntjes, An Claes, Willeke AM Blokx, Marie-Jeanne P Gerritsen, Dirk J Ruiter, Goos NP van Muijen

Journal:

The Journal of Pathology

Year:

2004

Language:

english

File:

PDF, 636 KB

english, 2004

6

COL3A1 2209G>A is a predictor of pelvic organ prolapse

Kirsten B. Kluivers, Jeroen R. Dijkstra, Jan C. M. Hendriks, Sabrina L. Lince, Mark E. Vierhout, Léon C. L. van Kempen

Journal:

International Urogynecology Journal

Year:

2009

Language:

english

File:

PDF, 131 KB

english, 2009

7

Pelvic organ prolapse and collagen-associated disorders

Karin Lammers, Sabrina L. Lince, Marian A. Spath, Léon C. L. T. van Kempen, Jan C. M. Hendriks, Mark E. Vierhout, Kirsten B. Kluivers

Journal:

International Urogynecology Journal

Year:

2012

Language:

english

File:

PDF, 164 KB

english, 2012

8

Hemoglobin level predicts outcome for vulvar cancer patients independent of GLUT-1 and CA-IX expression in tumor tissue

Hedwig P. van de Nieuwenhof, Joanne A. de Hullu, Johannes H. A. M. Kaanders, Johan Bulten, Leon F. A. G. Massuger, Léon C. L. T. van Kempen

Journal:

Virchows Archiv

Year:

2010

Language:

english

File:

PDF, 695 KB

english, 2010

9

Activated leukocyte cell adhesion molecule (ALCAM/CD166): Signaling at the divide of melanoma cell clustering and cell migration?

Guido W. M. Swart, Pim C. Lunter, Jeroen W. J. van Kilsdonk, Leon C. L. T. van Kempen

Journal:

Cancer and Metastasis Reviews

Year:

2005

Language:

english

File:

PDF, 357 KB

english, 2005

10

Truncation of Activated Leukocyte Cell Adhesion Molecule: A Gateway to Melanoma Metastasis

van Kempen, Leon C. L. T., Meier, Friedegund, Egeblad, Mikala, Kersten-Niessen, Monique J. F., Garbe, Claus, Weidle, Ulrich H., van Muijen, Goos N. P., Herlyn, Meenhard, Bloemers, Henri P. J., Swart,

Journal:

The Journal of Investigative Dermatology

Year:

2004

Language:

english

File:

PDF, 1.62 MB

english, 2004

11

Loss of membranous Ep-CAM in budding colorectal carcinoma cells

Gosens, Marleen J E M, van Kempen, Léon C L, van de Velde, Cornelis J H, van Krieken, J Han J M, Nagtegaal, Iris D

Journal:

Modern Pathology

Year:

2007

Language:

english

File:

PDF, 772 KB

english, 2007

12

Specific intraepithelial localization of mast cells in differentiated vulvar intraepithelial neoplasia and its possible contribution to vulvar squamous cell carcinoma development

Hedwig P Van De Nieuwenhof, Konny M Hebeda, Johan Bulten, Irene Otte-Holler, Leon F A G Massuger, Joanne A De Hullu, Leon C L T Van Kempen

Journal:

Year:

2010

Language:

english

File:

PDF, 1.45 MB

english, 2010

13

The prognostic value of blood and lymph vessel parameters in lichen sclerosus for vulvar squamous cell carcinoma development: an immunohistochemical and electron microscopy study

Irene A.M. van der Avoort, Jeroen A.W.M. van der Laak, Irene Otte-Höller, Hedwig P. van de Nieuwenhof, Leon F.A.G. Massuger, Joanne A. de Hullu, Léon C.L.T. van Kempen

Journal:

American Journal of Obstetrics and Gynecology

Year:

2010

Language:

english

File:

PDF, 1.92 MB

english, 2010

14

Tumours can adapt to anti-angiogenic therapy depending on the stromal context: Lessons from endothelial cell biology

Léon C.L. van Kempen, William P.J. Leenders

Journal:

European Journal of Cell Biology

Year:

2006

Language:

english

File:

PDF, 403 KB

english, 2006

15

Melanoma progression in a changing environment

Léon C.L. van Kempen, Goos N.P. van Muijen, Dirk J. Ruiter

Journal:

European Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

16

Soluble adhesion molecules in human cancers: Sources and fates

Jeroen W.J. van Kilsdonk, Léon C.L.T. van Kempen, Goos N.P. van Muijen, Dirk J. Ruiter, Guido W.M. Swart

Journal:

European Journal of Cell Biology

Year:

2010

Language:

english

File:

PDF, 483 KB

english, 2010

17

Activated leukocyte cell adhesion molecule expression predicts lymph node metastasis in oral squamous cell carcinoma

Michiel van den Brand, Robert P. Takes, Marianne Blokpoel-deRuyter, Piet J. Slootweg, Léon C.L. van Kempen

Journal:

Year:

2010

Language:

english

File:

PDF, 402 KB

english, 2010

18

MMP9 potentiates pulmonary metastasis formation

Léon C.L van Kempen, Lisa M Coussens

Journal:

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

19

Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment

Léon C.L. van Kempen, Jin-Sae Rhee, Kerstin Dehne, Jake Lee, Lisa M. Coussens, Dylan R. Edwards, Lisa M. Coussens

Journal:

Differentiation

Year:

2002

Language:

english

File:

PDF, 790 KB

english, 2002

20

The tumor microenvironment: a critical determinant of neoplastic evolution

Léon C.L.T. van Kempen, Dirk J. Ruiter, Goos N.P. van Muijen, Lisa M. Coussens

Journal:

European Journal of Cell Biology

Year:

2003

Language:

english

File:

PDF, 456 KB

english, 2003

21

Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression

Kempen, Léon C., Hurk, Karin, Lazar, Vladimir, Michiels, Stefan, Winnepenninckx, Véronique, Stas, Marguerite, Spatz, Alan, Oord, Joost J.

Journal:

Virchows Archiv

Year:

2012

Language:

english

File:

PDF, 322 KB

english, 2012

22

BIBX1382BS, but Not AG1478 or PD153035, Inhibits the ErbB Kinases at Different Concentrations in Intact Cells

Mikala Egeblad, Ole H. Mortensen, Léon C.L.T. van Kempen, Marja Jäättelä

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 312 KB

english, 2001

23

Inflammation, proteases and cancer

Léon C.L. van Kempen, Karin E. de Visser, Lisa M. Coussens

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 1.34 MB

english, 2006

24

Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age

Hedwig P. van de Nieuwenhof, Leon F.A.G. Massuger, Irene A.M. van der Avoort, Ruud L.M. Bekkers, Mariel Casparie, Wim Abma, Léon C.L.T. van Kempen, Joanne A. de Hullu

Journal:

European Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 282 KB

english, 2009

25

Activated Leukocyte Cell Adhesion Molecule/CD166, a Marker of Tumor Progression in Primary Malignant Melanoma of the Skin

Léon C.L.T. van Kempen, Joost J. van den Oord, Goos N.P. van Muijen, Ulrich H. Weidle, Henri P.J. Bloemers, Guido W.M. Swart

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 2.02 MB

english, 2000

26

Semaphorin 3E Expression Correlates Inversely with Plexin D1 During Tumor Progression

Ilse Roodink, Gürsah Kats, Léon van Kempen, Meritha Grunberg, Cathy Maass, Kiek Verrijp, Jos Raats, William Leenders

Journal:

The American Journal of Pathology

Year:

2008

Language:

english

File:

PDF, 886 KB

english, 2008

27

GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells

Delphine Javelaud, Vasileia-Ismini Alexaki, Marie-Jeanne Pierrat, Keith S. Hoek, Sylviane Dennler, Leon Van Kempen, Corine Bertolotto, Robert Ballotti, Simon Saule, Véronique Delmas, Alain Mauviel

Journal:

Pigment Cell & Melanoma Research

Year:

2011

Language:

english

File:

PDF, 7.38 MB

english, 2011

28

A systematic review of clinical studies on hereditary factors in pelvic organ prolapse

Lince, Sabrina L., Kempen, Leon C., Vierhout, Mark E., Kluivers, Kirsten B.

Journal:

International Urogynecology Journal

Year:

2012

Language:

english

File:

PDF, 275 KB

english, 2012

29

The dual role of the X-linked FoxP3 gene in human cancers

Margaret Redpath, Bin Xu, Leon C. van Kempen, Alan Spatz

Journal:

Molecular Oncology

Year:

2011

Language:

english

File:

PDF, 212 KB

english, 2011

30

EORTC Melanoma Group achievements

Alessandro Testori, Stefan Suciu, Alexander C.J. van Akkooi, Martin Cook, Ghanem Ghanem, R. Karra Gurunath, Ulrich Keilholz, Leon van Kempen, Serge Leyvraz, Martin Mihm, Julia Newton-Bishop, Poulam Pa

Journal:

European Journal of Cancer Supplements

Year:

2012

Language:

english

File:

PDF, 209 KB

english, 2012

31

A Possible Role for MicroRNA-141 Down-Regulation in Sunitinib Resistant Metastatic Clear Cell Renal Cell Carcinoma Through Induction of Epithelial-to-Mesenchymal Transition and Hypoxia Resistance

Berkers, Joost, Govaere, Olivier, Wolter, Pascal, Beuselinck, Benoit, Schöffski, Patrick, van Kempen, Léon C., Albersen, Maarten, Van den Oord, Joost, Roskams, Tania, Swinnen, Johan, Joniau, Steven, V

Journal:

The Journal of Urology

Year:

2013

Language:

english

File:

PDF, 2.26 MB

english, 2013

32

Responses of the Azolla filiculoides Stras.–Anabaena azollae Lam. association to elevated sodium chloride concentrations: Amino acids as indicators for salt stress and tipping point

van Kempen, Monique M.L., Smolders, Alfons J.P., Bögemann, Gerard M., Lamers, Leon L.M., Visser, Eric J.W., Roelofs, Jan G.M.

Journal:

Year:

2013

Language:

english

File:

PDF, 525 KB

english, 2013

33

From biomarker development towards implementation of multidimensional biomarker panels in a clinical setting

van Kempen, Léon C., Spatz, Alan

Journal:

Molecular Oncology

Year:

2014

Language:

english

File:

PDF, 185 KB

english, 2014

34

Collagen type III alpha 1 polymorphism (rs1800255, COL3A1 2209 G>A) assessed with high-resolution melting analysis is not associated with pelvic organ prolapse in the Dutch population

Lince, Sabrina L., van Kempen, Leon C., Dijkstra, Jeroen R., IntHout, Joanna, Vierhout, Mark E., Kluivers, Kirsten B.

Journal:

International Urogynecology Journal

Year:

2014

Language:

english

File:

PDF, 166 KB

english, 2014

35

5th Canadian Melanoma Conference: research frontiers

van Kempen, Léon C

Journal:

Expert Review of Anticancer Therapy

Year:

2011

Language:

english

File:

PDF, 192 KB

english, 2011

36

Molecular pathology of cutaneous melanoma

van Kempen, Léon C, Redpath, Margaret, Robert, Caroline, Spatz, Alan

Journal:

Melanoma Management

Year:

2014

Language:

english

File:

PDF, 1.52 MB

english, 2014

37

Concurrent Endometrial Intraepithelial Carcinoma (EIC) and Serous Ovarian Cancer

Roelofsen, Thijs, van Kempen, Léon C.L.T., van der Laak, Jeroen A.W.M., van Ham, Maaike A., Bulten, Johan, Massuger, Leon F.A.G.

Journal:

International Journal of Gynecological Cancer

Year:

2012

Language:

english

File:

PDF, 3.14 MB

english, 2012

38

Factors impeding the acceptability and use of malaria preventive measures: implications for malaria elimination in eastern Rwanda

Ingabire, Chantal Marie, Rulisa, Alexis, Van Kempen, Luuk, Muvunyi, Claude, Koenraadt, Constantianus JM, Van Vugt, Michele, Mutesa, Leon, Van Den Borne, Bart, Alaii, Jane

Journal:

Malaria Journal

Year:

2015

Language:

english

File:

PDF, 414 KB

english, 2015

39

The Role of eIF4E in Response and Acquired Resistance to Vemurafenib in Melanoma

Zhan, Yao, Dahabieh, Michael S, Rajakumar, Arjuna, Dobocan, Monica C, M’Boutchou, Marie-Noël, Goncalves, Christophe, Shiru L., Lucy, Pettersson, Filippa, Topisirovic, Ivan, van Kempen, Léon, del Rincó

Journal:

The Journal of Investigative Dermatology

Year:

2015

Language:

english

File:

PDF, 5.17 MB

english, 2015

40

Modulation of Activated Leukocyte Cell Adhesion Molecule–Mediated Invasion Triggers an Innate Immune Gene Response in Melanoma

van Kilsdonk, Jeroen W J, Takahashi, Nozomi, Weidle, Ulrich, Burtscher, Helmut, Jarry, Jonathan, Daha, Mohamed R, Swart, Guido W M, van Kempen, Léon C L T

Journal:

The Journal of Investigative Dermatology

Year:

2012

Language:

english

File:

PDF, 2.17 MB

english, 2012

41

Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma

van de Nieuwenhof, Hedwig P, Bulten, Johan, Hollema, Harrie, Dommerholt, Rianne G, Massuger, Leon F A G, van der Zee, Ate G J, de Hullu, Joanne A, van Kempen, Leon C L T

Journal:

Modern Pathology

Year:

2011

Language:

english

File:

PDF, 377 KB

english, 2011

42

Biallelic NTHL1 Mutations in a Woman with Multiple Primary Tumors

Rivera, Barbara, Castellsagué, Ester, Bah, Ismaël, van Kempen, Léon C., Foulkes, William D.

Journal:

New England Journal of Medicine

Year:

2015

Language:

english

File:

PDF, 468 KB

english, 2015

43

p53 Reactivation by PRIMA-1Met (APR-246) sensitises V600E/KBRAF melanoma to vemurafenib

Krayem, Mohammad, Journe, Fabrice, Wiedig, Murielle, Morandini, Renato, Najem, Ahmad, Salès, François, van Kempen, Leon C., Sibille, Catherine, Awada, Ahmad, Marine, Jean-Christophe, Ghanem, Ghanem

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 2.12 MB

english, 2016

44

Identification of Six Loci Associated With Pelvic Organ Prolapse Using Genome-Wide Association Analysis

Allen-Brady, Kristina, Cannon-Albright, Lisa, Farnham, James M., Teerlink, Craig, Vierhout, Mark E., van Kempen, Léon C. L., Kluivers, Kirsten B., Norton, Peggy A.

Journal:

Obstetrics & Gynecology

Year:

2011

Language:

english

File:

PDF, 1.13 MB

english, 2011

45

Interacting effects of atmospheric CO 2 enrichment and solar radiation on growth of the aquatic fern Azolla filiculoides

van Kempen, Monique M. L., Smolders, Alfons J. P., Bögemann, Gerard M., Lamers, Leon P. M., Roelofs, Jan G. M.

Journal:

Freshwater Biology

Year:

2016

Language:

english

File:

PDF, 226 KB

english, 2016

46

A tool for easily predicting short-term phosphorus mobilization from flooded soils

Tang, Yingying, Van Kempen, Monique M.L., Van der Heide, Tjisse, Manschot, Johan J.A., Roelofs, Jan G.M., Lamers, Leon P.M., Smolders, Alfons J.P.

Journal:

Ecological Engineering

Year:

2016

Language:

english

File:

PDF, 625 KB

english, 2016

47

Reactive oxygen species in melanoma and its therapeutic implications

Wittgen, Hanneke G.M., van Kempen, Léon C.L.T.

Journal:

Melanoma Research

Year:

2007

Language:

english

File:

PDF, 151 KB

english, 2007

48

Keratinocytes drive melanoma invasion in a reconstructed skin model

Van Kilsdonk, Jeroen W.J., Bergers, Mieke, Van Kempen, Léon C.L.T., Schalkwijk, Joost, Swart, Guido W.M.

Journal:

Melanoma Research

Year:

2010

Language:

english

File:

PDF, 544 KB

english, 2010

49

Azolla along a phosphorus gradient: biphasic growth response linked to diazotroph traits and phosphorus-induced iron chlorosis

Temmink, Ralph J. M., Harpenslager, Sarah F., Smolders, Alfons J. P., van Dijk, Gijs, Peters, Roy C. J. H., Lamers, Leon P. M., van Kempen, Monique M. L.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.34 MB

english, 2018

50

Afatinib in Osimertinib-Resistant EGFR ex19del / T790M / P794L mutated Non-Small Cell Lung Cancer

van Kempen, Léon C., Wang, Hangjun, Aguirre, Maria Leonor, Spatz, Alan, Kasymjanova, Goulnar, Vilacha, Juliana F., Groves, Matthew R., Agulnik, Jason, Small, David

Journal:

Journal of Thoracic Oncology

Year:

2018

Language:

english

File:

PDF, 387 KB

english, 2018

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